Porter A, Mager A, Birnbaum Y, Strasberg B, Sclarovsky S, Rechavia E
Department of Cardiology, Rabin Medical Center, Petah Tiqva, Israel.
Clin Cardiol. 1999 Nov;22(11):762-3. doi: 10.1002/clc.4960221122.
Since its introduction to the market in March 1997, sildenafil acetate (Viagra) has been prescribed to 1.7 million people. Sixteen men who were taking the drug have died, 7 of them during or soon after sexual activity. Most of these data have been derived from the media and not from the scientific literature. There is a general impression that cardiovascular complications of sildenafil occur mainly when the drug is taken concomitantly with nitrates. We describe a 65-year-old man with known coronary artery disease who had an acute myocardial infarction shortly after taking sildenafil and engaging an sexual activity. The patient had not been using nitrates. We suggest that the emotional arousal induced by Viagra, followed by the heavy physical exertion during sexual activity, triggers plaque rupture that leads to acute myocardial infarction.
自1997年3月西地那非醋酸酯（伟哥）投放市场以来，已有170万人服用过该药。16名服用该药的男性死亡，其中7人在性行为期间或之后不久死亡。这些数据大多来自媒体而非科学文献。人们普遍认为，西地那非的心血管并发症主要发生在该药与硝酸盐类药物同时服用时。我们描述了一名65岁患有冠状动脉疾病的男性，他在服用西地那非并进行性行为后不久发生了急性心肌梗死。该患者未使用硝酸盐类药物。我们认为，伟哥引起的情绪兴奋，随后性行为期间的剧烈体力消耗，引发了斑块破裂，导致急性心肌梗死。
