Zarrindast M R, Mousa-Ahmadi E
Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Iran. zarinmr(@)nrcgeb.ac.ir
Eur J Pharmacol. 1999 Sep 24;381(2-3):129-33. doi: 10.1016/s0014-2999(99)00546-4.
The effect of GABA (gamma-aminobutyric acid system) receptor agonists and antagonists on naloxone-induced jumping in morphine-dependent mice was examined. Intraperitoneal (i.p.) or intracerebroventricular (i.c.v.) injection of different doses of the GABA(B) receptor agonist, baclofen (2.5, 5 and 10 mg/kg), reduced naloxone-induced jumping in morphine-dependent mice. The i.p. administration of the GABA(B) receptor antagonist, CGP35348 (P-[3-aminopropyl]-p-diethoxymethyl-phosphinic acid), but not the i.c.v. injection of the drug, increased naloxone-induced jumping. The antagonist also decreased the baclofen response. Administration of the GABA(A) receptor agonist, muscimol, but not the GABA(A) receptor antagonists bicuculline and picrotoxin, decreased the naloxone response in morphine-dependent animals. It is concluded that both GABA(A) and GABA(B) receptor subtypes may have an inhibitory influence on naloxone-induced withdrawal jumping in mice.
研究了γ-氨基丁酸（GABA）受体激动剂和拮抗剂对吗啡依赖小鼠纳洛酮诱发跳跃反应的影响。腹腔注射（i.p.）或脑室内注射（i.c.v.）不同剂量的GABA(B)受体激动剂巴氯芬（2.5、5和10mg/kg）可减少吗啡依赖小鼠纳洛酮诱发的跳跃反应。腹腔注射GABA(B)受体拮抗剂CGP35348（P-[3-氨基丙基]-p-二乙氧基甲基膦酸）可增加纳洛酮诱发的跳跃反应，但脑室内注射该药物则无此作用。该拮抗剂还可降低巴氯芬的反应。给予GABA(A)受体激动剂蝇蕈醇可降低吗啡依赖动物的纳洛酮反应，而给予GABA(A)受体拮抗剂荷包牡丹碱和印防己毒素则无此作用。结论是，GABA(A)和GABA(B)受体亚型可能对小鼠纳洛酮诱发的戒断性跳跃反应均有抑制作用。
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