肌动蛋白动力学的调控：LIM激酶的联系。

Regulation of actin dynamics: The LIM kinase connection.

作者信息

Lawler S

机构信息

Centre for Molecular Medicine, Royal Free and University College Medical School, Rayne Institute, 5 University Street, London, WC1E 6JJ, UK.

出版信息

Curr Biol. 1999 Nov 4;9(21):R800-2. doi: 10.1016/s0960-9822(99)80493-x.

DOI:10.1016/s0960-9822(99)80493-x

PMID:10556082

Abstract

A signalling pathway has recently been delineated that connects Rho-family GTPases to the cytoskeleton via LIM kinase and the F-actin depolymerising protein cofilin. The existence of this pathway helps to explain some of the effects of LIM kinase and cofilin in the control of actin dynamics.

摘要

最近已经描绘出一条信号通路，该通路通过LIM激酶和F-肌动蛋白解聚蛋白丝切蛋白将Rho家族GTP酶与细胞骨架相连。这条通路的存在有助于解释LIM激酶和丝切蛋白在控制肌动蛋白动力学中的一些作用。