Shapiro S D
Departments of Pediatrics, Medicine, and Cell Biology and Physiology, Washington University School of Medicine at St. Louis Children's Hospital, St. Louis, Missouri.
Am J Respir Crit Care Med. 1999 Nov;160(5 Pt 2):S29-32. doi: 10.1164/ajrccm.160.supplement_1.9.
Macrophages are the predominant defense cell in the normal lung and during conditions associated with chronic inflammation such as COPD. However, the role of the macrophage in the development of COPD has been controversial. Scientific evidence from a variety of sources is emerging that supports a primary role for the macrophage in regulating the inflammatory response and tissue destruction associated with COPD. The role of macrophage proteinases in the development of emphysema, a major component of COPD, will be discussed. Shapiro SD. The macrophage in chronic obstructive pulmonary disease.
巨噬细胞是正常肺组织以及慢性炎症相关疾病（如慢性阻塞性肺疾病，COPD）中的主要防御细胞。然而，巨噬细胞在COPD发生发展中的作用一直存在争议。来自各种来源的科学证据不断涌现，支持巨噬细胞在调节与COPD相关的炎症反应和组织破坏中起主要作用。本文将讨论巨噬细胞蛋白酶在肺气肿（COPD的主要组成部分）发生发展中的作用。夏皮罗·SD。慢性阻塞性肺疾病中的巨噬细胞。
