Jacobsen B B, Peitersen B, Hummer L
Acta Paediatr Scand. 1979 Mar;68(2):257-64. doi: 10.1111/j.1651-2227.1979.tb04998.x.
A total number of 27 premature infants with idiopathic respiratory distress syndrome (IRDS) and 52 healthy controls with comparable gestational age and body weights were studied during the first month of life. In infants with IRDS a reduced thyrotropin (TSH) response to birth was suggested, as serum TSH was lower in IRDS patients than in controls during the first two days of life. Low serum concentrations of thyroid hormones were found in the acute stage of IRDS reaching minimal values by day 3--5. After that period an increase in thyroid hormone levels occurred. The serum T2 increased to the level of healthy prematures by day 6--10, whereas the serum T4 increased to normal levels by day 21--30. Serum concentrations of thyroxine-binding globulin (TBG) were significantly lower in IRDS patients than in healthy controls; a gradual increase to normal levels occurred during recovery. Serum prealbumin (TBPA) levels in IRDS infants increased rapidly after birth and exceeded levels of healthy infants. Serum albumin values were not significantly different in the two groups of infants. The serum T4/TBG ratios were low during recovery from IRDS.
对27例患有特发性呼吸窘迫综合征（IRDS）的早产儿和52例胎龄及体重相当的健康对照婴儿在出生后的第一个月进行了研究。在患有IRDS的婴儿中，提示出生时促甲状腺激素（TSH）反应降低，因为在出生后的前两天，IRDS患者的血清TSH低于对照组。在IRDS的急性期发现甲状腺激素血清浓度较低，在第3 - 5天达到最低值。在此之后甲状腺激素水平升高。血清T2在第6 - 10天升至健康早产儿的水平，而血清T4在第21 - 30天升至正常水平。IRDS患者的甲状腺素结合球蛋白（TBG）血清浓度显著低于健康对照组；在恢复过程中逐渐升至正常水平。IRDS婴儿出生后血清前白蛋白（TBPA）水平迅速升高，并超过健康婴儿的水平。两组婴儿的血清白蛋白值无显著差异。IRDS恢复期间血清T4/TBG比值较低。
