Jacobsen B B, Peitersen B, Andersen H J, Hummer L
Acta Paediatr Scand. 1979 Jan;68(1):49-55. doi: 10.1111/j.1651-2227.1979.tb04429.x.
Simultaneous serum concentrations of thyroxine-binding globulin (TBG), prealbumin (TBPA) and albumin (Alb) were measured in 130 fullterm, 32 small-for-gestational age and 25 preterm infants during their first six days of life. In all infants serum concentrations of TBG were higher and serum TBPA and Alb were lower than in male adults. Even higher serum TBG levels were found in the mothers. There was no correlation between serum concentrations in paired maternal and cord sera. In infants with birth weights appropriate for gestation serum TBG, TBPA, and Alb concentrations increased progressively with gestational age. In small-for-gestational age infants born at term serum concentrations of TBG and Alb were lower than those in fullterm, but higher than those in premature newborns. Serum TBPA in small-for-gestational age babies was even lower than seen in prematures. A positive correlation was found between thyroid hormones and TBG concentrations, not between serum TBPA and thyroid hormones. The ratios between serum concentration of thyroid hormones and proteins might indicate that more thyroid hormonebinding sites are occupied in fullterm than in low birth-weight newborns. However, the main reason for the different serum levels of thyroid hormones in fullterm, small-for-gestational age and preterm babies is probably the various serum TBG concentrations demonstrated in these infants.
在130名足月儿、32名小于胎龄儿和25名早产儿出生后的头6天内，同时测定了血清甲状腺素结合球蛋白（TBG）、前白蛋白（TBPA）和白蛋白（Alb）的浓度。所有婴儿的血清TBG浓度均高于男性成年人，而血清TBPA和Alb浓度则低于男性成年人。母亲的血清TBG水平甚至更高。配对的母血和脐血血清浓度之间没有相关性。出生体重与孕周相符的婴儿，其血清TBG、TBPA和Alb浓度随孕周增加而逐渐升高。足月出生的小于胎龄儿血清TBG和Alb浓度低于足月儿，但高于早产儿。小于胎龄儿的血清TBPA甚至比早产儿还要低。甲状腺激素与TBG浓度之间呈正相关，而血清TBPA与甲状腺激素之间无相关性。甲状腺激素与蛋白质的血清浓度之比可能表明，足月儿比低出生体重新生儿有更多的甲状腺激素结合位点被占据。然而，足月儿、小于胎龄儿和早产儿血清甲状腺激素水平不同的主要原因可能是这些婴儿中所显示的不同血清TBG浓度。
