牛1号染色体与人类3号和21号染色体的平行RH定位

Parallel RH mapping of BTA1 with HSA3 and HSA21.

作者信息

Rexroad C E, Womack J E

机构信息

Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A&M University, College Station, Texas 77843, USA.

出版信息

Mamm Genome. 1999 Nov;10(11):1095-7. doi: 10.1007/s003359901168.

DOI:10.1007/s003359901168

PMID:10556430

Abstract

The development of radiation hybrid (RH) panels has elevated comparative gene mapping to a new level of resolution. In this study, we have constructed parallel RH maps defining rearrangements of gene order within conserved segments of bovine Chromosome (Chr) 1 (BTA1) and human Chrs 3 and 21 (HSA3, HSA21). Six new markers, including one gene, have been added to the bovine map, and 11 human genes were ordered with the human G3 panel. BTA1 is clearly a composite of genetic material conserved on these two human chromosomes with HSA21 homologs at each end of BTA1 flanking a large segment homologous to HSA3. Each of the three conserved segments of BTA1 contains rearrangements of gene order relative to their human counterparts.

摘要

辐射杂种（RH）板的发展已将比较基因图谱提升到了一个新的分辨率水平。在本研究中，我们构建了平行的RH图谱，确定了牛染色体（Chr）1（BTA1）以及人类Chr 3和21（HSA3、HSA21）保守区段内基因顺序的重排。六个新标记（包括一个基因）已添加到牛图谱中，并且11个人类基因通过人类G3板进行了排序。BTA1显然是这两条人类染色体上保守遗传物质的组合，BTA1两端是HSA21同源物，中间是与HSA3同源的大片段。BTA1的三个保守区段中的每一个相对于其人类对应区段都存在基因顺序的重排。