变形链球菌与毒力相关的抗原——抗体的产生

Antigens of Streptococcus mutans implicated in virulence--production of antibodies.

作者信息

Ciardi J E, Bowen W H, Reilly J A, Hsu S D, Gomez I, Kuzmiak-Jones H, Cole M F

出版信息

Adv Exp Med Biol. 1978;107:281-92. doi: 10.1007/978-1-4684-3369-2_33.

Abstract

The present studies assayed antibody activities in serum and saliva of animals immunized by different routes, with cells of S. mutans or cell-free preparations containing GTF, FTF, LTA and/or dextranase synthesized by S. mutans. The results show that the type of immunogenic preparation and the route of its administration can elicit different antibody response and may in part explain the disparity of results achieved by different investigators. The results further emphasize the need to use standardized preparations and carefully described protocols for vaccination.

摘要

本研究检测了通过不同途径用变形链球菌细胞或含有变形链球菌合成的葡糖基转移酶（GTF）、果糖基转移酶（FTF）、脂磷壁酸（LTA）和/或葡聚糖酶的无细胞制剂免疫的动物血清和唾液中的抗体活性。结果表明，免疫原性制剂的类型及其给药途径可引发不同的抗体反应，这在一定程度上可以解释不同研究者所取得结果的差异。结果进一步强调了使用标准化制剂和详细描述的疫苗接种方案的必要性。