仓鼠龋齿模型中葡糖基转移酶抗原的交叉保护作用
Cross-protective aspects of glucosyltransferase antigens in the hamster caries model.
作者信息
Smith D J, Taubman M A, Ebersole J L
出版信息
Adv Exp Med Biol. 1978;107:271-9. doi: 10.1007/978-1-4684-3369-2_32.
PMID:742487
Abstract
- Glucosyltransferase serotypes a and g are closely related antigenically but are more distantly related to GTF of serotype c, based on assays of inhibition of total glucan synthesis. 2) Local immunization with GTF from serotype c S. mutans reduces the colonization, caries, and lesions caused by infection with the homologous strain compared with sham injected controls. 3) Local immunization with GTF of serotype c S. mutans reduces the colonization, caries, and lesions caused by infection with S. mutans of serotype g (strain 6715).
摘要
- 根据对总葡聚糖合成抑制的测定，葡糖基转移酶血清型a和g在抗原性上密切相关，但与血清型c的葡糖基转移酶的关系较远。2) 与假注射对照组相比，用变形链球菌血清型c的葡糖基转移酶进行局部免疫可减少同源菌株感染引起的定植、龋齿和病变。3) 用变形链球菌血清型c的葡糖基转移酶进行局部免疫可减少血清型g（菌株6715）变形链球菌感染引起的定植、龋齿和病变。
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