Marlière V, Beylot-Barry M, Beylot C, Doutre M
Department of Dermatology, Haut-Lévêque Hospital, University of Bordeaux, Pessac, France.
Dermatology. 1999;199(2):153-5. doi: 10.1159/000018224.
We report a case of subcorneal pustular dermatosis (SPD) first treated with dapsone with poor response. Dapsone was changed to acitretin, which dramatically improved the lesions in a few days. Dapsone is the first-line treatment in SPD, but it may be ineffective in some cases and its toxicity is important. Therapeutic alternatives are limited and less effective (systemic corticosteroids, phototherapy). Our observation underlines the usefulness of retinoids, when dapsone is ineffective or poorly tolerated. Their effectiveness is comparable, but they are effective more rapidly and are better tolerated. A dose maintenance is necessary to avoid relapses. Their action in SPD remains unclear but may be due to the inhibition of neutrophil functions.
我们报告了1例角层下脓疱性皮肤病（SPD）患者，最初使用氨苯砜治疗，效果不佳。氨苯砜更换为阿维A后，皮损在数天内显著改善。氨苯砜是SPD的一线治疗药物，但在某些情况下可能无效，且其毒性不容忽视。治疗选择有限且效果较差（全身用皮质类固醇、光疗）。我们的观察结果强调，当氨苯砜无效或耐受性差时，维甲酸类药物是有用的。它们的疗效相当，但起效更快且耐受性更好。需要维持剂量以避免复发。它们在SPD中的作用尚不清楚，但可能是由于抑制了中性粒细胞功能。
