Okada Y, Kobayashi M, Neo M, Shinzato S, Matsushita M, Kokubo T, Nakamura T
Department of Orthopaedic Surgery, Faculty of Medicine, Kyoto University, Kawahara-cho 54, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan.
J Biomed Mater Res. 2000 Jan;49(1):106-11. doi: 10.1002/(sici)1097-4636(200001)49:1<106::aid-jbm13>3.0.co;2-w.
We developed a composite (ABC) consisting of alumina bead powder as an inorganic filler and bisphenol-a-glycidyl dimethacrylate (Bis-GMA)-based resin as an organic matrix. Alumina bead powder was manufactured by fusing crushed alpha-alumina powder and quenching it. The beads took a spherical form 3 microm in average diameter. The proportion of filler in the composites was 70% w/w. The composite was implanted into rat tibiae and cured in situ. Specimens were prepared 1, 2, 4, and 8 weeks after the operation and observed by transmission electron microscopy. The results were compared with those of a bone composite made of alpha-alumina powder (alpha-ALC). In ABC-implanted tibiae, the uncured surface layer of Bis-GMA-based resin was completely filled with newly formed bonelike tissue 2 weeks after implantation. The alumina bead fillers were surrounded by and in contact with bonelike tissue. No intervening soft tissue was seen. In alpha-ALC-implanted tibiae, a gap was always observed between the alpha-ALC and the bonelike tissue. These results indicate that the ABC has osteoconductivity, although the precise mechanism is still unclear.
我们研发了一种复合材料（ABC），其由作为无机填料的氧化铝珠粉和作为有机基体的双酚A - 缩水甘油二甲基丙烯酸酯（Bis - GMA）基树脂组成。氧化铝珠粉是通过将粉碎的α - 氧化铝粉熔融并淬火制成的。这些珠子呈球形，平均直径为3微米。复合材料中填料的比例为70%（重量/重量）。将该复合材料植入大鼠胫骨并在原位固化。在手术后1、2、4和8周制备标本，并通过透射电子显微镜观察。结果与由α - 氧化铝粉制成的骨复合材料（α - ALC）的结果进行比较。在植入ABC的胫骨中，植入后2周，Bis - GMA基树脂的未固化表层完全被新形成的类骨组织填充。氧化铝珠填料被类骨组织包围并与之接触。未见中间软组织。在植入α - ALC的胫骨中，总是在α - ALC和类骨组织之间观察到间隙。这些结果表明ABC具有骨传导性，尽管确切机制仍不清楚。
