Rodriguez A, Regnault A, Kleijmeer M, Ricciardi-Castagnoli P, Amigorena S
Institut National de la Santé et de la Recherche Médicale U520, Institut Curie, Section de Recherche, 75005 Paris, France.
Nat Cell Biol. 1999 Oct;1(6):362-8. doi: 10.1038/14058.
In order for cytotoxic T cells to initiate immune responses, peptides derived from internalized antigens must be presented to the cytotoxic T cells on major histocompatibility complex (MHC) class I molecules. Here we show that dendritic cells, the only antigen-presenting cells that initiate immune responses efficiently, have developed a unique membrane transport pathway linking the lumen of endocytic compartments and the cytosol. Endosome-to-cytosol transport is restricted to dendritic cells, specific to internalized antigens and selective for the size of the transported molecules. Thus, in dendritic cells, internalized antigens gain access to the cytosolic antigen-processing machinery and to the conventional MHC class I antigen-presentation pathway.
为了使细胞毒性T细胞启动免疫反应，内化抗原衍生的肽必须在主要组织相容性复合体（MHC）I类分子上呈递给细胞毒性T细胞。我们在此表明，树突状细胞是唯一能有效启动免疫反应的抗原呈递细胞，它已形成一种独特的膜转运途径，将内吞小室的腔与细胞质连接起来。内体到细胞质的转运仅限于树突状细胞，对内化抗原具有特异性，且对转运分子的大小具有选择性。因此，在树突状细胞中，内化抗原能够进入细胞质中的抗原加工机制以及传统的MHC I类抗原呈递途径。
