Department of Emergency and Critical Care Center, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Department of Emergency Medicine, Qilu Hospital of Shandong University, Jinan, China.
Front Immunol. 2024 May 21;15:1415573. doi: 10.3389/fimmu.2024.1415573. eCollection 2024.
Efferocytosis, the process of engulfing and removing apoptotic cells, plays an essential role in preserving tissue health and averting undue inflammation. While macrophages are primarily known for this task, dendritic cells (DCs) also play a significant role. This review delves into the unique contributions of various DC subsets to efferocytosis, highlighting the distinctions in how DCs and macrophages recognize and handle apoptotic cells. It further explores how efferocytosis influences DC maturation, thereby affecting immune tolerance. This underscores the pivotal role of DCs in orchestrating immune responses and sustaining immune equilibrium, providing new insights into their function in immune regulation.
噬作用，即吞噬和清除凋亡细胞的过程，在维持组织健康和避免过度炎症方面起着至关重要的作用。虽然巨噬细胞主要负责这项任务，但树突状细胞（DC）也起着重要作用。本综述深入探讨了各种 DC 亚群对噬作用的独特贡献，强调了 DC 和巨噬细胞识别和处理凋亡细胞的方式的区别。它进一步探讨了噬作用如何影响 DC 的成熟，从而影响免疫耐受。这凸显了 DC 在协调免疫反应和维持免疫平衡方面的关键作用，为其在免疫调节中的功能提供了新的见解。
