Hungin A P, Rubin G, O'Flanagan H
Centre for Health Studies, University of Durham.
Br J Gen Pract. 1999 Jun;49(443):463-4.
Long-term proton pump inhibitor (PPI) prescribing in general practice is common, but only a minority of patients request their prescriptions regularly. This study determined factors linked with compliance using questionnaires and diary cards. The chief factors determining whether or not patients took their PPIs were the presence or severity of symptoms and the desire to remain in personal control, together with a fear of side-effects and lack of knowledge about the drugs. As most such prescribing is for uncomplicated gastro-oesophageal reflux disease, on-demand therapy should now be formally advocated.
在普通医疗实践中,长期开具质子泵抑制剂(PPI)的处方很常见,但只有少数患者会定期索要他们的处方。本研究通过问卷调查和日记卡确定了与依从性相关的因素。决定患者是否服用PPI的主要因素是症状的存在或严重程度、保持自我控制的愿望,以及对副作用的恐惧和对药物缺乏了解。由于大多数此类处方是用于治疗非复杂性胃食管反流病,现在应正式提倡按需治疗。