免疫组织化学在骨髓戈谢细胞研究中的应用：一例报告
Immunohistochemistry applied to the study of bone marrow Gaucher's cells: a case report.
作者信息
Alterini R, Rigacci L, Stefanacci S, Innocenti F, Santini V, Carrai V, Rossi Ferrini P
机构信息
Department of Haematology, University of Florence, Italy.
出版信息
Eur J Histochem. 1999;43(3):235-9.
PMID:10563256
Abstract
Gaucher's disease is frequently associated with immunologic abnormalities, e.g. hypergammaglobulinemia, polyclonal gammopathy and benign monoclonal gammopathy. A patient with Gaucher's disease and a selective accumulation of IgM k in Gaucher's cells without serum monoclonal gammopathies is described. The selective accumulation is detected by immunohistochemistry analysis performed on cryostat bone marrow biopsies.
摘要
戈谢病常与免疫异常相关，例如高球蛋白血症、多克隆丙种球蛋白病和良性单克隆丙种球蛋白病。本文描述了一名患有戈谢病且在戈谢细胞中有IgM κ选择性蓄积但无血清单克隆丙种球蛋白病的患者。通过对低温恒温器保存的骨髓活检标本进行免疫组织化学分析检测到这种选择性蓄积。
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