Merkies I S, Schmitz P I, Samijn J P, van der Meché F G, van Doorn P A
Department of Neurology, Erasmus University Medical Centre Rotterdam, The Netherlands.
Neurology. 1999 Nov 10;53(8):1648-54. doi: 10.1212/wnl.53.8.1648.
To determine the prevalence and severity of ongoing fatigue and to investigate the internal consistency, reliability, and validity of the Fatigue Severity Scale (FSS) in patients with immune-mediated polyneuropathies.
The FSS was assessed in 113 patients who either experienced Guillain-Barré syndrome in the past or currently have a stable, chronic, inflammatory demyelinating polyradiculoneuropathy or a polyneuropathy associated with a monoclonal gammopathy of undetermined significance, and in 113 age- and sex-matched healthy controls. Data on four additional scales (Medical Research Council sumscore, functional grading scale [f-score], INCAT sensory sumscore, medical outcome study 36-items health survey [SF-36]) were obtained in all patients. SF-36 also was assessed in 59 controls.
"Severe" fatigue (FSS scores > or =95th percentile values in controls) was present in 80% of the patients. Fatigue was not significantly related to general strength, sensory deficits, f-score, and duration of symptoms. Severe fatigue was reported in 81% to 86% of patients with normal strength or sensation. Eighty percent of the patients (controls, 12%) reported their fatigue being among the three most disabling symptoms. SF-36 health status scores in the patient group were significantly lower than the obtained values of the controls and partially related to the FSS scores. Good internal consistency, significant reliability, and validity were obtained for the FSS.
Fatigue is a major symptom in patients with immune-mediated polyneuropathies and may persist for years after apparent recovery. The Fatigue Severity Scale seems appropriate for assessing fatigue in these patients because good internal consistency, reliability, and validity were demonstrated.
确定持续性疲劳的患病率和严重程度，并研究疲劳严重程度量表（FSS）在免疫介导性多发性神经病患者中的内部一致性、可靠性和有效性。
对113例既往患有吉兰-巴雷综合征或目前患有稳定的慢性炎症性脱髓鞘性多发性神经根神经病或与意义未明的单克隆丙种球蛋白病相关的多发性神经病的患者，以及113例年龄和性别匹配的健康对照者进行FSS评估。所有患者还获得了另外四个量表的数据（医学研究委员会总分、功能分级量表[f评分]、INCAT感觉总分、医学结局研究36项健康调查[SF-36]）。59例对照者也进行了SF-36评估。
80%的患者存在“严重”疲劳（FSS评分高于或等于对照组第95百分位数）。疲劳与总体力量、感觉缺陷、f评分和症状持续时间无显著相关性。81%至86%力量或感觉正常的患者报告有严重疲劳。80%的患者（对照组为12%）报告疲劳是最致残的三种症状之一。患者组的SF-36健康状况评分显著低于对照组的得分，且部分与FSS评分相关。FSS具有良好的内部一致性、显著的可靠性和有效性。
疲劳是免疫介导性多发性神经病患者的主要症状，且在明显恢复后可能持续数年。疲劳严重程度量表似乎适用于评估这些患者的疲劳，因为已证明其具有良好的内部一致性、可靠性和有效性。
