一名从急性发展为慢性养鸟人肺疾病患者支气管肺泡灌洗细胞和细胞因子的序贯变化

Sequential changes in bronchoalveolar lavage cells and cytokines in a patient progressing from acute to chronic bird Fancier's lung disease.

作者信息

Ohtani Y, Hisauchi K, Sumi Y, Miyashita Y, Sawada M, Miyake S, Yoshizawa Y

机构信息

Pulmonary Medicine, Tokyo Medical and Dental University.

出版信息

Intern Med. 1999 Nov;38(11):896-9. doi: 10.2169/internalmedicine.38.896.

DOI:10.2169/internalmedicine.38.896

PMID:10563753

Abstract

A 65-year-old pigeon breeder who presented with acute hypersensitivity pneumonitis refused to give up contact with pigeons and her lung disease, which had initially improved in hospital in response to removal from pigeons, progressed to chronic interstitial fibrosis. Bronchoalveolar lavage lymphocytes fell from 50.0% of total cells in December 1986 to 27.1% in February 1990. The ratio of CD4+/CD8+ lymphocytes shifted from 0.43 to 1.47. Furthermore, IL-6 and TNF-alpha were elevated initially and were much higher at the second time point. These data pointed to the importance of CD4+ lymphocytes, IL-6 and TNF-alpha in the development of pulmonary fibrosis.

摘要

一名65岁的鸽子饲养员因急性过敏性肺炎就诊，她拒绝停止与鸽子接触，其肺部疾病最初在医院因脱离鸽子接触而有所改善，但后来进展为慢性间质性纤维化。支气管肺泡灌洗淋巴细胞占总细胞的比例从1986年12月的50.0%降至1990年2月的27.1%。CD4+/CD8+淋巴细胞的比例从0.43变为1.47。此外，白细胞介素-6（IL-6）和肿瘤坏死因子-α（TNF-α）最初升高，在第二个时间点时更高。这些数据表明CD4+淋巴细胞、IL-6和TNF-α在肺纤维化发展过程中的重要性。