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[不同血型肺结核患者的免疫变化]

[The immunological changes caused by Mycobacterium tuberculosis in patients with different blood groups].

作者信息

Sybirna R I, Platonova I L, Sakhelashvili M I

机构信息

Scientific-Research Institute of Epidemiology and Hygiene, Lviv, Ukraine.

出版信息

Mikrobiol Z. 1999 Jul-Aug;61(4):54-8.

Abstract

The distribution of blood groups of ABO system among 285 primary revealed persons with tuberculosis of the respiratory organs was studied. The condition of T-, B-link immunity and immunospecific reactivity depending on the patient group belonging was analyzed. A tendency to the increase in the number of persons with O(I) and B(III) and decrease in those with A(II) blood group among the examined ones comparatively with the data of the control group was determined. Considerable depression of proliferative activity of T-lymphocytes of sick persons with O(I) and B(III) and specific immunity of patients with O(I) in comparison with A(II) was revealed. Probably, this fact creates the favorable background for origination and development of tuberculosis infection and explains the increase of the number of persons with pulmonary tuberculosis which possess these phenotypical features.

摘要

对285例初次发现的呼吸器官结核病患者的ABO血型系统分布进行了研究。分析了T、B淋巴细胞免疫状态及免疫特异性反应性与患者所属组别的关系。与对照组数据相比,确定了受检者中O(I)型和B(III)型血型人数增加、A(II)型血型人数减少的趋势。发现O(I)型和B(III)型患病者的T淋巴细胞增殖活性明显降低,与A(II)型患者相比,O(I)型患者的特异性免疫也明显降低。这一事实可能为结核感染的发生和发展创造了有利背景,并解释了具有这些表型特征的肺结核患者人数增加的原因。

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