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[既往患肺结核后有明显残留病变的慢性支气管炎患者的免疫情况]

[Immunity in chronic bronchitis patients with significant residual changes after prior pulmonary tuberculosis].

作者信息

Ditiatkov A E, Antonova O Iu, Shevelev V I, Rvacheva A V, Kaznacheeva E I, Beĭlina V B, Tkachev G A, Zykov K A

出版信息

Probl Tuberk Bolezn Legk. 2008(3):14-7.

Abstract

To study the immunological features in chronic bronchitis (CB) patients with great residual changes (GRC) after prior pulmonary tuberculosis, the authors examined two groups: 1) 40 CB patients with GRC after prior pulmonary tuberculosis (a study group) and 2) 30 CB patients without a history of pulmonary tuberculosis. The examination revealed that CB patients with GRC after prior pulmonary tuberculosis were found to have higher T lymphocytes, lower B lymphocytes on an exacerbation of the disease. The phagocytic properties of neutrophils were altered as their high phagocytic activity, decreased oxygen-dependent microbicidal activity of phagocytes with their stimulation. The humoral response remained to be slightly pronounced in CB bronchitis with GRC. The low serum levels of TBC active products may suggest the low activity of lipid peroxidation processes in the study group patients. After prior pulmonary tuberculosis, antioxidative activity preserves to be high in CB patients with GRC.

摘要

为研究既往有肺结核病史且有严重残留病变(GRC)的慢性支气管炎(CB)患者的免疫学特征,作者检查了两组:1)40例既往有肺结核病史且有GRC的CB患者(研究组)和2)30例无肺结核病史的CB患者。检查发现,既往有肺结核病史且有GRC的CB患者在疾病加重时T淋巴细胞较高,B淋巴细胞较低。中性粒细胞的吞噬特性发生改变,表现为吞噬活性高,吞噬细胞经刺激后氧依赖性杀菌活性降低。在有GRC的CB支气管炎中,体液反应仍略显明显。研究组患者血清中结核活性产物水平较低,可能提示脂质过氧化过程活性较低。既往有肺结核病史后,有GRC的CB患者抗氧化活性仍较高。

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