Mohan P S, Jaya Rao K S
Arch Dis Child. 1979 Jan;54(1):62-4. doi: 10.1136/adc.54.1.62.
Somatomedin activity was assayed in the plasma of children suffering from protein calorie malnutrition by a bioassay using rat cartilage and expressed as sulphate uptake ratio. The sulphate uptake ratio was particularly reduced in kwashiorkor. In marasmus there was a slight reduction and the levels were still in the normal range. Plasma growth hormone (GH) levels were raised in kwashiorkor but were in the normal range in marasmus. Reduction in sulphate uptake ratio was observed only when plasma albumin levels were less than 2.5 g/100 ml (25 g/l). A rise in plasma GH was also observed but only below this threshold level.
采用大鼠软骨生物测定法，对患有蛋白质 - 热量营养不良的儿童血浆中的生长调节素活性进行了测定，并以硫酸盐摄取率表示。夸希奥科病（恶性营养不良）患儿的硫酸盐摄取率显著降低。消瘦症患儿的硫酸盐摄取率略有降低，但仍在正常范围内。夸希奥科病患儿的血浆生长激素（GH）水平升高，但消瘦症患儿的血浆生长激素水平在正常范围内。仅当血浆白蛋白水平低于2.5 g/100 ml（25 g/l）时，才观察到硫酸盐摄取率降低。同时也观察到血浆GH升高，但仅在该阈值水平以下。
