Thomas A G, Holly J M, Taylor F, Miller V
Department of Gastroenterology, Booth Hall Children's Hospital, Blackley, Manchester.
Gut. 1993 Jul;34(7):944-7. doi: 10.1136/gut.34.7.944.
Twenty nine children with Crohn's disease were studied before and after treatment with steroids or an elemental diet to assess the effect of disease activity and treatment on serum insulin like growth factor I (IGF-I), insulin like growth factor binding protein (IGFBP-1), and insulin concentrations. The median serum IGF-I concentration was lower in patients with active disease than in matched controls, and lower in stunted than well grown patients, but insulin and IGFBP-1 concentrations were not significantly different between any group. After four weeks of either treatment there was an increase in the median serum IGF-I concentration; this was greater in the steroid group than the elemental diet group. The median serum insulin concentration increased and median serum IGFBP-1 concentration decreased in the steroid treated group but not in the elemental diet group. These changes were accompanied by a greater and more sustained increase in energy intake in the steroid group. Despite this the median height velocity SD score was greater in the elemental diet group than in the steroid group.
对29名克罗恩病患儿在接受类固醇或要素饮食治疗前后进行了研究，以评估疾病活动度和治疗对血清胰岛素样生长因子I（IGF-I）、胰岛素样生长因子结合蛋白（IGFBP-1）及胰岛素浓度的影响。活动期疾病患儿的血清IGF-I浓度中位数低于匹配的对照组，发育迟缓患儿低于生长良好的患儿，但胰岛素和IGFBP-1浓度在任何组间均无显著差异。两种治疗四周后，血清IGF-I浓度中位数均升高；类固醇组升高幅度大于要素饮食组。类固醇治疗组血清胰岛素浓度中位数升高，血清IGFBP-1浓度中位数降低，而要素饮食组则无变化。这些变化伴随着类固醇组能量摄入的增加幅度更大且更持久。尽管如此，要素饮食组的身高速度标准差评分中位数仍高于类固醇组。
