Oya T, Enoki T, Grosberg A Y, Masamune S, Sakiyama T, Takeoka Y, Tanaka K, Wang G, Yilmaz Y, Feld M S, Dasari R, Tanaka T
Department of Physics and Center for Materials Science and Engineering, Department of Chemistry, George R. Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Science. 1999 Nov 19;286(5444):1543-5. doi: 10.1126/science.286.5444.1543.
A general approach is presented for creating polymer gels that can recognize and capture a target molecule by multiple-point interaction and that can reversibly change their affinity to the target by more than one order of magnitude. The polymers consist of majority monomers that make the gel reversibly swell and shrink and minority monomers that constitute multiple-point adsorption centers for the target molecule. Multiple-point interaction is experimentally proven by power laws found between the affinity and the concentration of the adsorbing monomers within the gels.
本文提出了一种通用方法，用于制备聚合物凝胶，该凝胶可通过多点相互作用识别并捕获目标分子，且能使其对目标分子的亲和力可逆地改变超过一个数量级。这些聚合物由使凝胶可逆膨胀和收缩的多数单体以及构成目标分子多点吸附中心的少数单体组成。凝胶内吸附单体的亲和力与浓度之间的幂律在实验上证明了多点相互作用。
