Blanco Y, Ramos-Casals M, García-Carrasco M, Cervera R, Font J, Ingelmo M
Departamento de Medicina, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Hospital Clinic, Universitat de Barcelona.
Rev Clin Esp. 1999 Sep;199(9):586-8.
The antiphospholipid syndrome (APS) is characterized by the presence of venous and arterial thrombosis, fetal losses, and thrombocytopenia, associated with the presence of antiphospholipid antibodies (aPL). This syndrome may be "primary" or associated with other diseases, particularly systemic lupus erythematosus (SLE). There is considerable debate on the interrelations between primary APS and SLE as well as on the value of the American College of Rheumatology (ACR) criteria to distinguish between both entities. Several authors have suggested that some patients with primary APS may ultimately develop SLE. Likewise, some authors have proposed exclusion criteria for primary APS. The presence of any of these criteria in a patient with the initial diagnosis of APS might indicate progression of SLE. Three new cases are here reported in whom the diagnosis evolved into SLE some years after the initial diagnosis of primary APS was made. Similar cases previously reported in the literature are reviewed.
抗磷脂综合征（APS）的特征是存在静脉和动脉血栓形成、胎儿丢失及血小板减少，并伴有抗磷脂抗体（aPL）。该综合征可能为“原发性”，或与其他疾病相关，尤其是系统性红斑狼疮（SLE）。关于原发性APS与SLE之间的相互关系以及美国风湿病学会（ACR）标准在区分这两种疾病时的价值，存在相当多的争论。一些作者认为，部分原发性APS患者最终可能会发展为SLE。同样，一些作者也提出了原发性APS的排除标准。最初诊断为APS的患者若出现这些标准中的任何一项，可能提示SLE病情进展。本文报告了3例新病例，这些患者在最初诊断为原发性APS数年后，诊断演变为SLE。同时对文献中先前报道的类似病例进行了综述。
