Gurjal A, An T, Valdivieso M, Kalemkerian G P
The Department of Internal Medicine, Wayne State University and the Barbara Ann Karmanos Cancer Institute, Detroit, MI, USA.
Lung Cancer. 1999 Nov;26(2):109-12. doi: 10.1016/s0169-5002(99)00081-1.
After treatment with etoposide, two patients with lung cancer developed interstitial infiltrates and respiratory failure. Of the two, one patient responded rapidly to steroid therapy and developed recurrent symptoms on re-challenge with etoposide. Both patients had histopathologic findings consistent with drug-induced pulmonary toxicity. Etoposide-induced lung disease needs to be considered in patients who develop subacute dyspnea and interstitial infiltrates during treatment with this agent.
接受依托泊苷治疗后，两名肺癌患者出现间质性浸润和呼吸衰竭。其中一名患者对类固醇治疗反应迅速，但再次使用依托泊苷时症状复发。两名患者的组织病理学检查结果均符合药物性肺毒性。对于在使用该药物治疗期间出现亚急性呼吸困难和间质性浸润的患者，需要考虑依托泊苷引起的肺部疾病。
