Dajczman E, Srolovitz H, Kreisman H, Frank H
Department of Medicine, Sir Mortimer B. Davis-Jewish General Hospital, McGill University, Montreal, Quebec, Canada.
Lung Cancer. 1995 Mar;12(1-2):81-6. doi: 10.1016/0169-5002(94)00410-o.
Oral etoposide has considerable activity in small cell lung cancer and the low risk of toxicity has resulted in the frequent prescription of this agent in elderly or infirmed patients. We describe a case of fatal pulmonary toxicity following the administration of oral etoposide. This is the first report of biopsy-proven pulmonary toxicity associated with this agent.
口服依托泊苷对小细胞肺癌具有显著活性，且毒性风险较低，这使得该药物在老年或体弱患者中经常被处方使用。我们描述了一例口服依托泊苷后发生致命性肺毒性的病例。这是首例经活检证实与该药物相关的肺毒性报告。
