血细胞增生症细胞遗传学研究中的G带分析
G banding in cytogenetic study of hemoblastoses.
作者信息
Fleischman E W, Prigogina E L
出版信息
Humangenetik. 1975;26(4):335-42. doi: 10.1007/BF00285385.
G banding was used in the study of the karyotype of malignant cells in 10 patients: 5 with CML (3 in blastic crisis), 3 with AL and 2 with lymphosarcomas. In all cases of CML 22q-- (Ph1-chromosome) and 9q+ were present in leukemic cells. An i(17q) was observed in the karyotype of 2 out of 3 patients in blastic crisis of CML. In AL and lymphosarocmas small chromosome rearrangements were revealed and the origin of marker chromosomes could be established by the aid of G banding.
采用G显带技术对10例患者的恶性细胞染色体核型进行了研究：5例慢性粒细胞白血病（CML）患者（3例处于急变期），3例急性白血病（AL）患者和2例淋巴肉瘤患者。在所有CML病例中，白血病细胞均存在22号染色体长臂缺失（Ph1染色体）和9号染色体长臂增加。在3例CML急变期患者中，有2例的染色体核型中观察到17号染色体等臂染色体。在AL和淋巴肉瘤患者中发现了小的染色体重排，借助G显带技术可确定标记染色体的来源。
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