Loskutova L V
Institute of Physiology, Russian Academy of Medical Sciences, Siberian Branch, Novosibirsk.
Zh Vyssh Nerv Deiat Im I P Pavlova. 1999 Sep-Oct;49(5):808-16.
Latent inhibition (LI) is a reduction in the rate of acquisition of a conditioned response that results from repeated preexposure of an animal to a conditioned stimulus (CS). The present experiment was conducted to assess the effect of bilateral lesions of 5-OT terminals of the nucleus accumbens on LI in a conditioned passive avoidance response paradigm. The lesions were produced by administration of 5,7-DHT and resulted in disruption of LI. Sham-operated animals displayed the delay of conditioning (LI) in comparison with the non-preexposed controls. Disruption of the LI was prevented by systemic injection of haloperidol. Involvement of 5-HT substrate of the nucleus accumbens and its interaction with dopaminergic system in the process of the LI development is discussed.
潜伏抑制（LI）是指动物反复预先暴露于条件刺激（CS）后，条件反应习得率的降低。本实验旨在评估伏隔核5-羟色胺（5-OT）终末双侧损伤对条件性被动回避反应范式中LI的影响。通过给予5,7-二羟色胺（5,7-DHT）造成损伤，结果导致LI受到破坏。与未预先暴露的对照组相比，假手术动物表现出条件反射延迟（LI）。全身注射氟哌啶醇可防止LI的破坏。文中讨论了伏隔核5-羟色胺底物及其与多巴胺能系统在LI形成过程中的相互作用。
