Loskutova L V
Institute of Physiology, Siberian Division, Russian Academy of Medical Sciences, Novosibirsk.
Neurosci Behav Physiol. 2001 Jan-Feb;31(1):15-20. doi: 10.1023/a:1026613928155.
Latent inhibition is an effect consisting of a delay in the acquisition of a stimulus in response to quenching of its significance by repeated presentation (pre-exposure) before combination with the reinforcement. This phenomenon is used for studies of the mechanisms of attention. Experiments were performed on rats to determine whether latent inhibition could be formed in a passive avoidance response in conditions of blockade of serotoninergic terminals in the nucleus accumbens. After pre-exposure, sham-operated animals demonstrated a delay in acquisition of the stimulus as compared with animals not subjected to pre-exposure. Bilateral injection of the neurotoxin 5,7-dihydroxytryptamine into the nucleus accumbens led to disruption of latent inhibition, which could in turn be prevented by systemic administration of haloperidol before training. The importance of serotoninergic terminals in the nucleus accumbens for latent inhibition is discussed, along with the mechanism of their interaction with the dopaminergic system during the formation of this effect.
潜伏抑制是一种效应，它表现为在刺激与强化物结合之前，通过反复呈现（预暴露）使其意义消退，从而导致对该刺激的习得出现延迟。这种现象被用于注意力机制的研究。对大鼠进行了实验，以确定在伏隔核中5-羟色胺能终末被阻断的条件下，被动回避反应中是否能形成潜伏抑制。预暴露后，与未进行预暴露的动物相比，假手术动物表现出刺激习得的延迟。向伏隔核双侧注射神经毒素5,7-二羟基色胺会导致潜伏抑制的破坏，而在训练前全身给予氟哌啶醇则可以防止这种破坏。文中讨论了伏隔核中5-羟色胺能终末对潜伏抑制的重要性，以及在这种效应形成过程中它们与多巴胺能系统相互作用的机制。
