由致命先天性异常导致的婴儿死亡率的区域模式。
Regional patterns of infant mortality caused by lethal congenital anomalies.
作者信息
Wen S W, Liu S, Joseph K S, Trouton K, Allen A
机构信息
Bureau of Reproductive and Child Health, Laboratory Centre for Disease Control, Ottawa, ON.
出版信息
Can J Public Health. 1999 Sep-Oct;90(5):316-9. doi: 10.1007/BF03404519.
PURPOSE
To assess the regional patterns of infant mortality due to lethal congenital anomalies, and the potential reasons for the regional patterns.
METHOD
The study analyzed 2,507 infant deaths due to lethal congenital anomalies among 1,178,452 live births in 9 of the 12 Canadian provinces and territories from 1990 to 1995 recorded in Statistics Canada's live birth and death data bases.
RESULTS
Compared with the province of Quebec, congenital anomaly-attributed infant mortality was higher in Newfoundland, Saskatchewan, and Alberta. These differences in infant mortality were substantial for cardiovascular system anomalies and especially anencephaly. For infant mortality due to chromosomal anomalies, however, there was little inter-provincial variation.
CONCLUSIONS
Despite substantial recent reductions in lethal congenital anomaly-attributed infant mortality, there remain major regional variations in infant mortality caused by certain forms of congenital anomalies including anencephaly and cardiovascular system anomalies.
目的
评估因致命先天性异常导致的婴儿死亡率的区域模式，以及形成这些区域模式的潜在原因。
方法
该研究分析了1990年至1995年期间加拿大12个省和地区中的9个省和地区，在加拿大统计局的出生和死亡数据库中记录的1,178,452例活产中2,507例因致命先天性异常导致的婴儿死亡情况。
结果
与魁北克省相比，纽芬兰、萨斯喀彻温省和艾伯塔省因先天性异常导致的婴儿死亡率更高。这些婴儿死亡率差异在心血管系统异常尤其是无脑儿方面尤为显著。然而，对于因染色体异常导致的婴儿死亡率，省际差异很小。
结论
尽管近期因致命先天性异常导致的婴儿死亡率大幅下降，但某些形式的先天性异常（包括无脑儿和心血管系统异常）导致的婴儿死亡率仍存在重大区域差异。
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