Roncancio Claudia Patricia, Misnaza Sandra Patricia, Peña Isabel Cristina, Prieto Franklyn Edwin, Cannon Michael J, Valencia Diana
a Field Epidemiology Training Program , National Health Institute , Bogotá , Colombia.
b Sinergias ONG , Bogotá , Colombia.
J Matern Fetal Neonatal Med. 2018 Jul;31(13):1748-1755. doi: 10.1080/14767058.2017.1326901. Epub 2017 May 22.
To describe fetal and neonatal mortality due to congenital anomalies in Colombia.
We analyzed all fetal and neonatal deaths due to a congenital anomaly registered with the Colombian vital statistics system during 1999-2008.
The registry included 213,293 fetal deaths and 7,216,727 live births. Of the live births, 77,738 (1.08%) resulted in neonatal deaths. Congenital anomalies were responsible for 7321 fetal deaths (3.4% of all fetal deaths) and 15,040 neonatal deaths (19.3% of all neonatal deaths). The fetal mortality rate due to congenital anomalies was 9.9 per 10,000 live births and fetal deaths; the neonatal mortality rate due to congenital anomalies was 20.8 per 10,000 live births. Mortality rates due to congenital anomalies remained relatively stable during the study period. The most frequent fatal congenital anomalies were congenital heart defects (32.0%), central nervous system anomalies (15.8%), and chromosomal anomalies (8.0%). Risk factors for fetal and neonatal death included: male or undetermined sex, living in villages or rural areas, mother's age >35 years, low and very low birthweight, and <28 weeks gestation at birth.
Congenital anomalies are an important cause of fetal and neonatal deaths in Colombia, but many of the anomalies may be preventable or treatable.
描述哥伦比亚先天性异常所致的胎儿及新生儿死亡情况。
我们分析了1999年至2008年期间哥伦比亚生命统计系统登记的所有因先天性异常导致的胎儿及新生儿死亡病例。
该登记系统涵盖了213,293例胎儿死亡和7,216,727例活产。在活产中，77,738例（1.08%）导致新生儿死亡。先天性异常导致7321例胎儿死亡（占所有胎儿死亡的3.4%）和15,040例新生儿死亡（占所有新生儿死亡的19.3%）。先天性异常导致的胎儿死亡率为每10,000例活产和胎儿死亡中有9.9例；先天性异常导致的新生儿死亡率为每10,000例活产中有20.8例。在研究期间，先天性异常导致的死亡率相对稳定。最常见的致命先天性异常为先天性心脏病（32.0%）、中枢神经系统异常（15.8%）和染色体异常（8.0%）。胎儿及新生儿死亡的危险因素包括：男性或性别未确定、居住在村庄或农村地区、母亲年龄>35岁、低出生体重和极低出生体重以及出生时孕周<28周。
先天性异常是哥伦比亚胎儿及新生儿死亡的重要原因，但许多异常可能是可预防或可治疗的。
