重组复合干扰素与重组干扰素α-2b抗病毒活性的比较。
Comparison of an antiviral activity of recombinant consensus interferon with recombinant interferon-alpha-2b.
作者信息
Koyama A H, Arakawa T, Adachi A
机构信息
Department of Virology, School of Medicine, The University of Tokushima, Japan.
出版信息
Microbes Infect. 1999 Nov;1(13):1073-7. doi: 10.1016/s1286-4579(99)00210-5.
To avoid possible uncertainty in comparing biological activities of interferon samples from different sources where interferon concentrations were determined independently, we prepared chromatographically pure preparations of consensus interferon and interferon-alpha-2b (one of the two commercially available recombinant alpha interferons). We revealed that consensus interferon has a stronger antiviral activity than interferon-alpha-2b, although the effects of these two recombinant interferons on the cellular macromolecule synthesis are at similar levels.
为避免在比较来自不同来源且干扰素浓度独立测定的干扰素样品的生物活性时可能出现的不确定性，我们制备了色谱纯的共有干扰素和干扰素-α-2b（两种市售重组α干扰素之一）制剂。我们发现，共有干扰素的抗病毒活性比干扰素-α-2b更强，尽管这两种重组干扰素对细胞大分子合成的影响处于相似水平。
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