[Anti-SARS virus activities of different recombinant human interferons in cell culture system].
作者信息
Duan Zhao-jun, Zhang Li-lan, Xie Zhi-ping, Yu Zhi-ai, Zhang Li-ping, Zhang Bin, Liu Yong-qing, Wang Jian-wei, Li Wu-ping, Zhang Cheng-hai, Ma Xue-jun, Shu Yue-long, Duan Shu-min, Li De-xin, Hou Yun-de
机构信息
Beijing Jin Di Ke Biotechnology Institute, State Research Center for Biotechnological Engineering, Beijing 100176, China.
出版信息
Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2003 Sep;17(3):205-8.
BACKGROUND
To study the anti-SARS virus activities of different recombinant human interferons on the cell culture system.
METHODS
Anti-SARS virus activities of interferons were determined by using CPE inhibition test in human skeletal muscle sarcoma (Rda) cell culture.
RESULTS
The average minimum amount of interferon alpha 2b, alpha 1b, beta 1b or omega 1b to inhibit 50% CPE in Rda cell culture was (160.5+/-129.5) IU/ml, (149.0+/-71.7) IU/ml, (69.5+/-61.5) IU/ml, (87.3+/-47.1) IU/ml, respectively or (0.6+/-0.5) ng/ml, (10.6+/-5.1) ng/ml, (3.5+/-3.1) ng/ml, (0.9+/-0.5) ng/ml, respectively.
CONCLUSION
All the tested recombinant interferons showed anti-SARS virus activities on the Rda cell culture with different sensitivities.
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