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从埃及伊蚊中分离和鉴定一种与烟草天蛾促咽侧体素相关的肽及其cDNA。

Isolation and identification of a peptide and its cDNA from the mosquito Aedes aegypti related to Manduca sexta allatotropin.

作者信息

Veenstra J A, Costes L

机构信息

Department of Entomology and Center for Insect Science, University of Arizona, Tucson 85721, USA.

出版信息

Peptides. 1999;20(10):1145-51. doi: 10.1016/s0196-9781(99)00117-5.

DOI:10.1016/s0196-9781(99)00117-5
PMID:10573285
Abstract

Immunocytochemistry revealed that an allatotropin-immunoreactive peptide is produced by several neuroendocrince cells in the abdominal ganglia of the mosquito Aedes aegypti. The immunoreactive peptide was isolated and its structure determined to be Ala-Pro-Phe-Arg-Asn-Ser-Glu-Met-Met-Thr-Ala-Arg-Gly-Phe-amide. A cDNA clone encoding this novel neuropeptide was shown to encode a single copy of this peptide. The cDNA is unusual in that the first seven ATGs are not used for translation initiation.

摘要

免疫细胞化学研究显示，埃及伊蚊腹部神经节中的几个神经内分泌细胞可产生一种促咽侧体素免疫反应性肽。该免疫反应性肽被分离出来，其结构确定为丙氨酸-脯氨酸-苯丙氨酸-精氨酸-天冬酰胺-丝氨酸-谷氨酸-蛋氨酸-蛋氨酸-苏氨酸-丙氨酸-精氨酸-甘氨酸-苯丙氨酸-酰胺。编码这种新型神经肽的cDNA克隆显示只编码该肽的一个拷贝。该cDNA不同寻常之处在于前七个甲硫氨酸密码子不用于翻译起始。

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