Regele S, Kohlberger P, Vogl F D, Böhm W, Kreienberg R, Runnebaum I B
University of Ulm, Department of Obstetrics and Gynaecology, Germany.
Br J Cancer. 1999 Oct;81(4):702-4. doi: 10.1038/sj.bjc.6690751.
Five of 43 patients (11.6%) with ductal carcinoma in situ of the breast presented with p53 autoantibodies at diagnosis. Three seropositive patients demonstrated tumour sizes of < or = 5 mm. There was no association of p53 autoantibody status with age, clinical presentation, histological subtype, tumour size, grading, p53 immunohistochemistry or hormone receptor status.
43例乳腺导管原位癌患者中有5例(11.6%)在诊断时出现p53自身抗体。3例血清阳性患者的肿瘤大小≤5mm。p53自身抗体状态与年龄、临床表现、组织学亚型、肿瘤大小、分级、p53免疫组化或激素受体状态无关。