吸入谷胱甘肽对哮喘患者气道对“烟雾”激发反应的影响。
Effect of inhaled glutathione on airway response to 'Fog' challenge in asthmatic patients.
作者信息
Bagnato G F, Gulli S, De Pasquale R, Giacobbe O, Spatari G, Purello D'Ambrosio F
机构信息
Department of Internal Medicine, University of Messina, Italy.
出版信息
Respiration. 1999 Nov-Dec;66(6):518-21. doi: 10.1159/000029428.
OBJECTIVE
We report on the effect of glutathione, an antioxidant compound on the airway response to the ultrasonically nebulised distilled water (UNDW, 'fog') challenge.
METHODS
12 subjects with mild-to-moderate bronchial asthma underwent double-blind, cross-over pretreatment, administered 30 min earlier, in a randomised order with inhaled glutathione (G) (600 mg), sodium cromoglycate (SCG) (20 mg) and placebo (P), followed by the challenge.
RESULTS
After P pretreatment UNDW challenge caused a mean 20.41% decrease in FEV-1 (p < 0.05), after G, a mean 6.04% fall in FEV-1 (p = n.s.), and after SCG a mean 5.99% fall in FEV-1 (p = n.s.).
CONCLUSIONS
G significantly attenuated 'fog'-induced falls in FEV-1 (p < 0.001 compared with P) and showed a protective effect on UNDW-induced bronchoconstriction.
目的
我们报告了抗氧化化合物谷胱甘肽对气道对超声雾化蒸馏水（UNDW，“雾”）激发试验反应的影响。
方法
12名轻至中度支气管哮喘患者进行双盲、交叉预处理，提前30分钟随机依次吸入谷胱甘肽（G）（600毫克）、色甘酸钠（SCG）（20毫克）和安慰剂（P），随后进行激发试验。
结果
P预处理后，UNDW激发试验导致FEV-1平均下降20.41%（p<0.05），G预处理后，FEV-1平均下降6.04%（p无统计学意义），SCG预处理后，FEV-1平均下降5.99%（p无统计学意义）。
结论
G显著减轻了“雾”诱导的FEV-1下降（与P相比，p<0.001），并对UNDW诱导的支气管收缩显示出保护作用。
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