司托巴定对刺激的人多形核白细胞中氧自由基生成的影响。
Effect of stobadine on oxygen free radical generation in stimulated human polymorphonuclear leukocytes.
作者信息
Pecivová J, Drábiková K, Kotuliaková K, Macicková T, Nosál R, Danihelová E
机构信息
Institute of Experimental Pharmacology, Slovak Academy of Sciences, Bratislava, Slovak Republic.
出版信息
Life Sci. 1999;65(18-19):1987-9. doi: 10.1016/s0024-3205(99)00461-0.
The generation both superoxide and a mixture of reactive oxygen species was recorded in a suspension of human polymorphonuclear leukocytes stimulated with phorbol myristate acetate. While stobadine dose-dependently decreased chemiluminescence, only its highest concentration used reduced significantly superoxide generation. The results suggest that stobadine is a more effective scavenger of free radicals rather than a quencher of superoxide anion.
在用佛波酯刺激的人多形核白细胞悬液中记录到了超氧化物和活性氧混合物的产生。虽然司托巴定剂量依赖性地降低了化学发光，但只有其使用的最高浓度显著降低了超氧化物的产生。结果表明，司托巴定是一种更有效的自由基清除剂，而不是超氧阴离子猝灭剂。
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