Siminiak T, Wysocki H
Academy of Medicine, Institute of Internal Medicine, Poznan, Poland.
Agents Actions. 1992;Spec No:C104-5.
During myocardial ischemia and subsequent reperfusion, activation of polymorphonuclear neutrophils occurs and results in an increased production of oxygen free radicals that participate in the generation of reperfusion arrhythmias. We investigated the effect of antiarrhythmic drug lidocaine on oxygen free radicals production by activated neutrophils in vitro with a chemiluminescence assay. Lidocaine reduced lucigenin-amplified chemiluminescence related to the superoxide anion production but failed to affect hydrogen-peroxide dependent luminol chemiluminescence.
在心肌缺血及随后的再灌注过程中，多形核中性粒细胞被激活，导致氧自由基生成增加，而氧自由基参与了再灌注心律失常的发生。我们采用化学发光分析法，在体外研究了抗心律失常药物利多卡因对活化中性粒细胞产生氧自由基的影响。利多卡因减少了与超氧阴离子生成相关的光泽精增强化学发光，但未能影响依赖过氧化氢的鲁米诺化学发光。
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