Kaliszan R, Hać E
Pharmazie. 1976 Jul;31(7):453-6.
Specimens of carbromal obtained by crystallization from various solvents were analyzed. After a 9-month storage period, the occurrence of three polymorphic forms (I, II and III) was ascertained. The metastable form III obtained by crystallization from dimethylformamide showed a reasonably high stability. Preliminary pharmacological tests revealed clear-cut differences in the therapeutic effect between a commercial specimen and the polymorphic modification III. The results presented here indicate the importance of polymorphism of carbromal for medicinal use.
对通过从各种溶剂中结晶获得的溴米那普鲁卡因样本进行了分析。经过9个月的储存期后，确定出现了三种多晶型物（I、II和III）。通过从二甲基甲酰胺中结晶获得的亚稳型III显示出相当高的稳定性。初步药理试验显示，市售样本与多晶型物III之间在治疗效果上存在明显差异。此处给出的结果表明了溴米那普鲁卡因多晶型性在药用方面的重要性。
