治疗剂量三环类抗抑郁药物心血管副作用的评估

Assessment of cardiovascular side effects of therapeutic doses of tricyclic anti-depressant drugs.

作者信息

Vohra J, Burrows G D, Sloman G

出版信息

Aust N Z J Med. 1975 Feb;5(1):7-11. doi: 10.1111/j.1445-5994.1975.tb03247.x.

DOI:10.1111/j.1445-5994.1975.tb03247.x

Abstract

An assessment of the side effects of therapeutic doses of tricyclic anti-depressant drugs was attempted in 32 patients with depressive illness. The patients studied had no evidence of clinical heart disease or hypertension and were not receiving any other drugs. Moderate increase in heart rate and mild prolongation of atrioventricular conduction occurred. No significant effect on the corrected QT interval or blood pressure was found. There was no correlation between the increased heart rate, prolongation of the atrioventricular conduction time (PR interval) and plasma nortriptyline levels measured in 20 out of 32 patients.

摘要

对32例抑郁症患者尝试评估治疗剂量三环类抗抑郁药物的副作用。所研究的患者没有临床心脏病或高血压证据，且未服用任何其他药物。出现心率适度增加和房室传导轻度延长。未发现对校正QT间期或血压有显著影响。在32例患者中的20例中，心率增加、房室传导时间（PR间期）延长与血浆去甲替林水平之间无相关性。