通过三项家族研究探讨HL-A W27在强直性脊柱炎和赖特综合征中的意义。

The significance of HL-A W27 in ankylosing spondylitis and Reiter's syndrome with three family studies.

作者信息

Cross R A, Rigby R, Dawkins R L

出版信息

Aust N Z J Med. 1975 Apr;5(2):108-11. doi: 10.1111/j.1445-5994.1975.tb03637.x.

DOI:10.1111/j.1445-5994.1975.tb03637.x

Abstract

So as to test the diagnostic significance of tissue typing in an Australian population the HL-A antigens of forty-seven patients with Ankylosing Sondylitis and six patients with Reiter's Syndrome were compared with those found in three hundred and six controls. Since HL-A W27 was found in 92% of the patients with Ankylosing Spondylitis and all patients with Reiter's Syndrome it is concluded that these diagnoses should be questioned if this antigen cannot be demonstrated. In three family studies it was apparent that Ankylosing Spondylitis only occurred in those who had inherited HL-A W27 so that the absence of the antigen may help to identify those family members who will not develop the disease. Notwithstanding the association demonstrated the data argue against a close and simple linkage between the antigen and these diseases.

摘要

为了检验组织分型在澳大利亚人群中的诊断意义，将47例强直性脊柱炎患者和6例赖特综合征患者的HL-A抗原与306名对照者的HL-A抗原进行了比较。由于在92%的强直性脊柱炎患者和所有赖特综合征患者中都发现了HL-A W27，因此得出结论，如果无法证明该抗原，则应对这些诊断提出质疑。在三项家族研究中，很明显强直性脊柱炎仅发生在那些遗传了HL-A W27的人身上，因此该抗原的缺失可能有助于识别那些不会患该病的家庭成员。尽管已证明存在关联，但数据表明该抗原与这些疾病之间不存在紧密而简单的联系。