Breitfeld P P, Weisburd M, Overhage J M, Sledge G, Tierney W M
Regenstrief Institute, Indiana University School of Medicine, Indianapolis 46202-2859, USA.
J Am Med Inform Assoc. 1999 Nov-Dec;6(6):466-77. doi: 10.1136/jamia.1999.0060466.
Many adults with cancer are not enrolled in clinical trials because caregivers do not have the time to match the patient's clinical findings with varying eligibility criteria associated with multiple trials for which the patient might be eligible. The authors developed a point-of-use portable decision support tool (DS-TRIEL) to automate this matching process. The support tool consists of a hand-held computer with a programmable relational database. A two-level hierarchic decision framework was used for the identification of eligible subjects for two open breast cancer clinical trials. The hand-held computer also provides protocol consent forms and schemas to further help the busy oncologist. This decision support tool and the decision framework on which it is based could be used for multiple trials and different cancer sites.
许多成年癌症患者未参加临床试验,原因是护理人员没有时间将患者的临床检查结果与多个患者可能符合条件的试验所关联的不同入选标准进行匹配。作者开发了一种即时使用的便携式决策支持工具(DS - TRIEL)来自动执行这种匹配过程。该支持工具由一台带有可编程关系数据库的手持计算机组成。一个两级分层决策框架被用于识别两项开放性乳腺癌临床试验的合格受试者。手持计算机还提供方案同意书和图表,以进一步帮助忙碌的肿瘤学家。这种决策支持工具及其所基于的决策框架可用于多个试验和不同的癌症部位。