Synthesis of 11,12-epoxydrim-8,12-en-11-ol, 11,12-diacetoxydrimane, and warburganal from (-)-sclareol.

作者信息

Barrero A F, Cortés M, Manzaneda E A, Cabrera E, Chahboun R, Lara M, Rivas A R

机构信息

Departamento de Química Orgánica, Instituto de Biotecnología, Facultad de Ciencias, Universidad de Granada, Campus Fuentenueva s/n, 18071-Granada, Spain.

出版信息

J Nat Prod. 1999 Nov;62(11):1488-91. doi: 10.1021/np990140q.

DOI:10.1021/np990140q

PMID:10579858

Abstract

The first syntheses are reported for recently isolated drimanes 11, 12-epoxydrim-8,12-en-11-ol (2) and 11,12-diacetoxydrimane (3), from (-)-sclareol (1). Furthermore, two efficient new routes to the potent bioactive warburganal (4) starting also from 1 are described.

摘要