来自海绵直立扁海绵的细胞毒性半日花烷型倍半萜。

Cytotoxic scalarane sesterterpenes from a sponge, Hyrtios erecta.

作者信息

Tsuchiya N, Sato A, Hata T, Sato N, Sasagawa K, Kobayashi T

机构信息

Biomedical Research Laboratories, Sankyo Co. Ltd., Tokyo, Japan.

出版信息

J Nat Prod. 1998 Apr;61(4):468-73. doi: 10.1021/np970462z.

DOI:10.1021/np970462z

PMID:9584401

Abstract

Novel scalarane sesterterpenes (1-4) were isolated from a sponge, Hyrtios erecta (order Dictyoceratida). They were characterized by means of spectral analyses, X-ray crystallography, and chemical reactions. Compound 1 showed potent in vitro and in vivo antitumor activities. In addition, the structure-activity relationship was also discussed using computer-assisted structure matching of 1 and aragusterols.

摘要

新型半日花烷型倍半萜（1-4）从一种海绵——直立扁海绵（网角海绵目）中分离得到。通过光谱分析、X射线晶体学和化学反应对其进行了表征。化合物1在体外和体内均表现出较强的抗肿瘤活性。此外，还利用化合物1与刺参甾醇的计算机辅助结构匹配对构效关系进行了探讨。