Kumar A, Dhawan S, Mukhopadhyay A, Aggarwal B B
Cytokine Research Section, Department of Molecular Oncology, University of Texas M.D. Anderson Cancer Center, 1515 Holcombe St. Box 143, Houston, TX 77030, USA.
FEBS Lett. 1999 Nov 26;462(1-2):140-4. doi: 10.1016/s0014-5793(99)01487-8.
We have previously shown that human immunodeficiency virus (HIV)-1-tat induces the production of matrix metalloproteinase-9 (MMP-9) in human monocytes by a mechanism that is not understood. In the present report, we demonstrate that HIV-tat-induced expression of MMP-9 is blocked by inhibitors of protein tyrosine phosphatases (PTPases). PTPase inhibitors also blocked HIV-tat-induced nuclear transcription factor NF-kappaB activation and IkappaBalpha degradation required for MMP-9 induction. These results suggest that HIV-tat induces MMP-9 in human monocytes through activation of PTPase and NF-kappaB.
我们之前已经表明，人类免疫缺陷病毒1型（HIV-1）反式激活蛋白（tat）可通过一种尚不明确的机制诱导人单核细胞产生基质金属蛋白酶9（MMP-9）。在本报告中，我们证明HIV-tat诱导的MMP-9表达可被蛋白酪氨酸磷酸酶（PTPase）抑制剂阻断。PTPase抑制剂还可阻断HIV-tat诱导的MMP-9表达所需的核转录因子NF-κB激活及IκBα降解。这些结果表明，HIV-tat通过激活PTPase和NF-κB在人单核细胞中诱导MMP-9的产生。
