Chung E B, Enzinger F M
Cancer. 1975 Oct;36(4):1450-8. doi: 10.1002/1097-0142(197510)36:4<1450::aid-cncr2820360437>3.0.co;2-4.
The clinical and pathologic features of 53 cases of proliferative fasciitis, a pseudosarcomatous process involving fascia and interlobular fibrous septa of the subcutaneous fat, were reviewed. In the reviewed material, the lesion affected adults exclusively, with a high incidence in patients older than 40 years (median 54 years). It involved most commonly the upper and lower extremities, and microscopically was characterized by a diffuse infiltrative fibroblastic growth intimately associated with multifocal proliferation of large basophilic cells, closely resembling ganglion cells--a microscopic picture akin to proliferative myositis. In 16 of the 53 cases, the lesion had been initially confused with sarcoma because of its rapid growth and its bizarre histologic features. Although the term "proliferative fasciitis" has been used in the past as a symptom for nodular fasciitis, it is suggested that it be limited to the lesion under discussion, in order to emphasize its close relationship to proliferative myositis. Followup information revealed a benign clinical course. Therefore, despite its rapid growth and bizarre microscopic appearance, the lesion is adequately treated by local excision, and there is no indication for radical surgery.
回顾了53例增生性筋膜炎的临床和病理特征，这是一种累及皮下脂肪筋膜和小叶间纤维间隔的假肉瘤性病变。在所回顾的资料中，该病变仅累及成年人，40岁以上患者发病率较高（中位年龄54岁）。它最常累及上肢和下肢，显微镜下表现为弥漫性浸润性成纤维细胞生长，与大嗜碱性细胞的多灶性增殖密切相关，这些细胞酷似神经节细胞——这一显微镜图像类似于增生性肌炎。在53例病例中的16例中，由于病变生长迅速且组织学特征怪异，最初被误诊为肉瘤。尽管过去“增生性筋膜炎”一词曾被用作结节性筋膜炎的一种表现，但建议将其限定于所讨论的病变，以强调其与增生性肌炎的密切关系。随访信息显示其临床过程为良性。因此，尽管该病变生长迅速且显微镜下外观怪异，但通过局部切除即可得到充分治疗，无需进行根治性手术。
