一种用于经导管栓塞的快速聚合聚氨酯。
A rapidly polymerizing polyurethane for transcatheter embolization.
作者信息
Doppman J L, Aven W, Bowman R L, Wood L L, Girton M
出版信息
Cardiovasc Radiol. 1978 Apr 25;1(2):109-16. doi: 10.1007/BF02552004.
A polyurethane prepolymer was evaluated as a transcatheter embolizing agent. Low viscosity permits injection through small catheters. Polymerization is initated on contact with blood and completed within 10 seconds. Downstream propagation is better then that of cyanoacrylate and comparable to that of silicone rubber. No systemic toxicity was observed in acute animal experiments. However, dissolution of arterial walls and extravasation out of the vascular bed of chronically embolized organs suggest significant local tissue toxicity and make further evaluation necessary before clinical testing.
一种聚氨酯预聚物被评估用作经导管栓塞剂。低粘度使其能够通过小导管注射。与血液接触时引发聚合反应，并在10秒内完成。其下游扩散效果优于氰基丙烯酸酯，与硅橡胶相当。在急性动物实验中未观察到全身毒性。然而，慢性栓塞器官的动脉壁溶解和血管床外渗表明存在显著的局部组织毒性，因此在进行临床试验之前需要进一步评估。
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