Department of Radiology, Kagoshima University, Kagoshima, Japan.
Diagn Interv Radiol. 2013 Mar-Apr;19(2):141-4. doi: 10.4261/1305-3825.DIR.6086-12.1.
We aimed to investigate the potentiality of atelocollagen, a new embolic agent which is collagen type I in a porcine experimental model.
Three pigs underwent transcatheter embolization of lower interlobular arteries of the renal artery (n=6) and one branch of the hepatic artery (n=3) with collagen type I. Angiography was performed prearterial, during, and postarterial embolization. After the procedure, samples from the embolized organs were evaluated by histological analysis.
Six lower interlobular renal arteries and three hepatic arteries were successfully embolized by administration of 0.8±0.3 mL and 2.9±1.2 mL, respectively, of the collagen type I. Histological findings of the embolized kidney specimens showed that the collagenous materials filled the arterial lumen, whose size ranged from 2.02 to 839.82 μm and reached the level of afferent arteries of glomerular tufts. Although the area of occluded arteries of the liver was smaller than the kidney, histological findings of the liver specimens showed that the collagenous materials filled small arterial lumens from 2.81 to 187.86 μm in diameter.
Atelocollagen, a collagen type I, has the potential to be used to embolize the distal vessels of both renal and hepatic arteries.
我们旨在研究一种新型的栓塞剂——atelocollagen 的潜力，它是一种 I 型胶原蛋白，在猪的实验模型中。
3 只猪接受了经导管栓塞术，将胶原蛋白 I 注入肾动脉的小叶间下动脉（n=6）和肝动脉的一条分支（n=3）。在动脉栓塞前、期间和后进行血管造影。手术后，通过组织学分析评估栓塞器官的样本。
成功地用 0.8±0.3 mL 和 2.9±1.2 mL 的胶原蛋白 I 栓塞了 6 条小叶间肾动脉和 3 条肝动脉。栓塞肾标本的组织学发现表明，胶原物质充满了动脉腔，其大小范围从 2.02 到 839.82 μm，并到达肾小球丛的入球小动脉水平。虽然肝脏的闭塞动脉面积小于肾脏，但肝脏标本的组织学发现表明，胶原物质填充了直径从 2.81 到 187.86 μm 的小动脉腔。
atelocollagen，一种 I 型胶原蛋白，具有用于栓塞肾和肝动脉远端血管的潜力。
