Garon C L, Scott M A, Selting K A, Cohn L A
Department of Veterinary Medicine and Surgery, University of Missouri Veterinary Medical Teaching Hospital, Columbia 65211, USA.
J Am Anim Hosp Assoc. 1999 Nov-Dec;35(6):464-70. doi: 10.5326/15473317-35-6-464.
An 11-year-old, castrated, male domestic shorthair cat was presented for hematuria and pollakiuria. The cat had a marked thrombocytopenia, and a bone-marrow core biopsy demonstrated megakaryocytic hyperplasia with many megakaryocyte-associated neutrophils (i.e., emperipolesis). On peripheral blood, collected at initial presentation, what appeared to be platelets were noted to be within or adherent to occasional neutrophils. The thrombocytopenia was idiopathic in that no definitive cause could be found. However, platelet concentrations appeared to increase and decrease in response to changes in prednisone and cyclosporine therapy, suggesting a possible immune-mediated pathogenesis. As tests to detect increased feline platelet-associated antibodies are unavailable, immune-mediated thrombocytopenia can only be tentatively diagnosed in cats by exclusion and response to therapy.
一只11岁已绝育的雄性家养短毛猫因血尿和尿频前来就诊。该猫有明显的血小板减少症，骨髓芯活检显示巨核细胞增生，并伴有许多与巨核细胞相关的中性粒细胞（即细胞内吞作用）。在初次就诊时采集的外周血中，发现偶尔有中性粒细胞内或附着有看似血小板的物质。血小板减少症是特发性的，因为找不到确切病因。然而，血小板浓度似乎随着泼尼松和环孢素治疗的变化而增减，提示可能存在免疫介导的发病机制。由于尚无检测猫血小板相关抗体增加的试验，免疫介导的血小板减少症在猫中只能通过排除法和对治疗的反应进行初步诊断。
