Best M P, Fry D R
Brisbane Veterinary Specialist Centre, Cnr Old Northern and Keong Rds, Albany Creek, Queensland, 4035, Australia.
Aust Vet J. 2014 Jul;92(7):250-3. doi: 10.1111/avj.12186.
A 21-week-old Maine Coon cat presented with an acute-onset coagulopathy. Severe concurrent thrombocytopenia and neutropenia were identified on peripheral blood smears and bone marrow cytology supported a peripheral consumptive process. Other than mild superficial haemorrhage, the cat was clinically well and screening for retroviral diseases, abdominal ultrasound examination, thoracic radiography, haematology and biochemistry panels did not identify an underlying disease. There was no historical pharmaceutical or toxicological trigger noted and the cat was from an area without endemic Ehrlichia spp. There was a rapid resolution of both cytopenias following treatment with immunosuppressive doses of prednisolone, though a mild relapse occurred during gradual prednisolone withdrawal and was responsive to a dose increase.
This report describes this combination of diseases for the first time in a cat and presents a younger patient than previously described with feline primary immune-mediated haematological disease.
一只21周大的缅因猫出现急性凝血功能障碍。外周血涂片检查发现严重的并发血小板减少症和中性粒细胞减少症，骨髓细胞学检查支持外周消耗性过程。除轻度浅表出血外，该猫临床状况良好，对逆转录病毒疾病进行筛查、腹部超声检查、胸部X光检查、血液学和生化检查均未发现潜在疾病。未发现有药物或毒理学诱因史，该猫来自无地方性埃立希体属的地区。用免疫抑制剂量的泼尼松龙治疗后，两种血细胞减少症均迅速缓解，不过在逐渐停用泼尼松龙期间出现轻度复发，增加剂量后有反应。
本报告首次描述了猫身上这种疾病组合，并呈现了比之前报道的患有猫原发性免疫介导血液疾病的患者更年轻的病例。
