Makashova N V, Babenkova I V, Teselkin Iu O
Vestn Oftalmol. 1999 Sep-Oct;115(5):3-4.
Antioxidant activity (AOA) of lacrimal fluid and blood plasma was studied in 10 normal subjects (20 eyes) and 35 patients with primary open-angle glaucoma (POAG) (67 eyes with glaucoma at different stages). The findings indicate that the progress of glaucoma is paralleled by a gradual decrease in the lacrimal fluid AOA, which becomes significant at the third stage of POAG. Plasma AOA also decreased significantly in the third far advanced stage. A course of total antioxidant therapy including oral aevit and vitamin complexes and intramuscular ascorbic acid normalized plasma AOA even in patients with far advanced glaucoma, while the lacrimal AOA did not normalize. Therefore, local antioxidants are preferable in glaucoma patients.
对10名正常受试者（20只眼）和35例原发性开角型青光眼（POAG）患者（67只处于不同阶段的青光眼患眼）的泪液和血浆抗氧化活性（AOA）进行了研究。研究结果表明，青光眼进展过程中泪液AOA逐渐降低，在POAG第三阶段时显著降低。在晚期第三阶段血浆AOA也显著下降。包括口服维生素E和复合维生素以及肌肉注射抗坏血酸在内的全抗氧化剂治疗疗程，即使对晚期青光眼患者也能使血浆AOA恢复正常，而泪液AOA未恢复正常。因此，青光眼患者使用局部抗氧化剂更为可取。
